STD (acronym) Type: noun, slang, acronym Pronunciation: /s-t-d/ Also spelled as: S.T.D. or S-T-D Plural: STDs What does STD mean or stand for? Sexually Transmitted Disease. STD Synonyms: Cupid’s itch Example sentence: “Don’t catch an STD messing with junkies.” STD in songs: “I thank the Lord I made it out, no STD” – Mac Miller, […]