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Re-up (slang) Type: verb, slang Pronunciation: /re-up/ Also spelled or known as: Reup, Re up What does Re-up mean? To replenish or refill one’s drug supply when it gets low. Example sentence: “I was running low on weed i had to Re-up.” Re-up in songs: “Friends with the dopeman, help a nigga re-up” – Childish […]