Nyquil (slang) Type: noun, slang Pronunciation: /ny-kwill/ What does Nyquil mean? A cold medicine for sleep. Example sentence: “I have a cold, i need Nyquil.” Nyquil in songs: “On the grind like copin’, no time to bring the dope in But this Nyquil got me feeling lit” – Logic, Innermission. “Real country-ass nigga, let me […]