LSD (slang) Type: noun, slang, acronym Pronunciation: /l-s-d/ Also spelled: L.S.D. What does LSD mean and stand for? Lysergic acid diethylamide; a synthetic hallucinogenic drug. Example sentence: “You don’t want to have a bad LSD trip at a party.” LSD in songs: “Chance, ho, acid, cruising on that LSD” – Chance the Rapper, Favorite Song. […]