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XO (acronym) Type: noun, acronym Pronunciation: /x-oh/ Also spelled: X.O. Related: XOXO What does XO mean and stand for? 1. Hugs and kisses.  XO Synonyms: XOXO 2. Ecstasy and Oxycodone.  3. The Weeknd’s Label XO. Similar to XO: TDE, MMG, QC, OVO, YSL, OTF, GBE, OPM, YMCMB, A$AP, YM, BDB, YNW, FBG, YBN, OFWGKTA, Freebandz, […]